Oxidization stress by active
oxygen and free radicals is considered to be closely related to the development
of symptoms of various geriatric diseases and the progression of aging. A method
of measuring stress accurately and easily is in great demand.
As an index
used for diagnosis and treatment, coenzyme Q10, vitamin C, vitamin E, and
glutathione that indicate anti-oxidization effect in the human body are
receiving great attention.
Among them, reduced coenzyme Q10 is sensitive to
oxidization by active oxygen and free radicals and produces oxidized coenzyme
Q10. Therefore, the ratio of oxidized coenzyme Q10 to total coenzyme Q10 may be
a sensitive marker for oxidization stress.
Shiseido, with its optimum
catalytic column (reduction column) for high-sensitivity analysis of quinone
derivatives, developed an analytical system for CoQ10 by combining an
electrochemical detector and a reduction column.
